Miscellaneous Questions

MISCELLANEOUS QUESTIONS FOR PHARMACY EXAMS (PEBC EE, NAPLEX)

1) The thyroid gland secretes which one of the following

hormones?

A) Insulin
B) Inulin
C) triiodothyronine
D) TRH
E) TSH

2) Which of the following is not a physiological effect controlled by thyroxine

A) Regulate growth and development
B) Calorigenic effects
C) Inhibition of gamma-carboxylation of Xa
D) Cardiovascular effects
E) Metabolic effects

3) Which statement correctly describes an effect of ACTH?

A) ACTH stimulates synthesis and secretion of cortisol
B) ACTH reduces conversion of proinsulin to insulin
C) ACTH inhibits conversion of HDL to LDL
D) ACTH inhibits synthesis and secretion of cortisol
E) ACTH dominates regulation of caloric metabolism
 

4) Which of the statements is correct?

A) A decrease in T3/T4 causes release of pituitary TSH
B) An increase in T3/T4 causes release of pituitary TSH
C) An increase in T3/T4 increases T4 synthesis and release
D) A decrease in T3/T4 decreases release of T4
E) Rates of T4 synthesis and release are not regulated by T3/T4 levels
 

5) Propylthiouracil is a drug that:

A) stimulates T3 and T4 synthesis
B) inhibits iodide trapping
C) inhibits thyroidal peroxidase
D) inhibits iodide organification
E) is another name for thyroxine-binding globulin

 

6) Which of the following statements is not correct?

A) Cortisol regulates carbohydrate, protein and fat metabolism
B) Cortisol increases gluconeogenesis and glycogen synthesis
C) Cortisol decreases excitability of neural tissues
D) Cortisol increases mobilization of proteins and amino acids
F) Cortisol increases mobilization of peripheral fat
 

7) Iodide trapping is the process by which:

A) Table salt is prepared
B) Iodide is incorporated into tyrosine
C) Iodide is taken transported into the thyroid
D) Iodide is incorporated into T3
E) Iodide is incorporated into T4
 

8) Graves disease in adults is best treated with:

A) The antithyroid drug methimazole
B) The antithyroid drug propylthiouracil
C) The thyroid hormone levothyroxine
D) Radioactive iodide
E) Non-radioactive iodide salts

9) Which of the following is NOT correct?

A) Glucocorticoids influence the function of most cells in the body
B) Glucocorticoids stimulate protein synthesis in liver
C) Glucocorticoids have catabolic effects in muscle
D) Glucocorticoids stimulate amino acid uptake by the liver
E) Glucocorticoids inhibit amino acid uptake by the liver

10) Prednisone is to Fludrocortisone as

A) Cortisol is to hydrocortisone
B) Cushing's syndrome is to Addison's disease
C) Prednisone is to Prednisolone
D) Prednisone is to methylprednisolone
E) Prednisolone is to Fludrocortisone

11)  Which of the following is not correct?

A) Aldosterone is synthesized in the zona glomerulosa of the adrenal cortex
B) Aldosterone secretion is regulated by ACTH
C) Aldosterone is a mineralocorticoid
D) Aldosterone is commonly used therapeutically
E) Aldosterone and Fludrocortisone are both mineralocorticoids

12) Which of the following is not correct?

A) Steroids are safe and are usually first line drugs for many conditions
B) Doses of steroids should be individualized
C) Steroids are almost always only palliative and not curative
D) Abrupt cessation of steroids can cause adrenal insufficiency
E) Smallest effective dose of steroids should be used

13) Insulin resistance refers to which of the following phenomenon?

A)  Inability to secrete insulin in response to glucose
B) Inability to break down proinsulin
C) Inability of bovine insulin to be solubilized
D) Inability of tissues to react to insulin
E) Autoimmune destruction of pancreatic beta cells

14)  Compared to insulin levels observed in non-diabetics, insulin levels
     in Type II diabetes is:

A)  Reduced
B) Normal or slightly elevated
C) Virtually abscent
D) Markedly increased
E) Markedly decreased

15) Compared to insulin levels observed in non-diabetics, insulin levels
     in Type I diabetes are:

A)  Reduced
B)  Normal or slightly elevated
C)  Virtually abscent
D)  Markedly increased
E)  Markedly decreased

 

16)  Of the following, which is not a type of injectable insulin?

A)  NPH insulin
B)  Protamine zinc insulin
C)  Lente insulin
D)  Ultrarapid insulin
E)  Ultralente Insulin

17)  Sulfonylureas:

A)  Inhibit insulin release
B)  Stimulate glucagon release
C)  Stimulate insulin release
D)  Inhibit immune destruction of insulin secreting cells
E)  Have no effect on insulin release

18)  Estrogens are NOT prescribed for which of the following?

A)  Primary Hypogonadism
B)  Postmenopausal hormone therapy
C)  Postmenopausal bleeding
D)  Suppress ovulation
E)  Hyperpigmentation

19)  Which of the following is not a female contraceptive?

A) Loestrin 1/20
B) Desogen
C) Ovral
D) Gossypol
E) Triphasil

20)  Mifepristone acts by:

A)  Binding to estrogen receptors
B)  Binding to glucocorticoid receptors
C)  Binding to testosterone receptors
D)  Promoting progesterone regulation of gene expression
E)  Binding to progesterone receptors

 

21)  Heparin is an anticoagulant since it:
A)  Inhibits maturation of clotting factors
B)  Promotes fibrin formation
C)  Promotes fibrinolysis
D)  Promotes inactivation of thrombin
E)  Promotes release of endothelial factors

22)  Compared to unfractionated heparin, which of the following is NOT an advantage of low molecular weight heparin?

A)  Less protein binding
B) Response more predictable
C) Preferentially catalysis inhibition of thrombin
D) Can be self-administered
E) Less thrombocytopenia

23)  Which of the following does not apply to Warfarin?

A)  Rapid onset of action
B) Inhibits reduction of vitamin K
C) Is taken orally
D) Inhibits maturation of coagulation factors
E) Effects can be reversed by administration of Vitamin K

24)  The main advantage of tPA for use as a fibrinolytic agent:

A)  Very inexpensive
B) is purified from human sources
C) Is selective for fibrin-bound plasminogen
D) Is not immunogenic
E) Inhibits platelets