Exercise # 3

PRACTICE QUESTIONS

EXERCISE # 3

21- Which of the followings is true about AUC?

I – It depends on both rate and extent of drug absorption

II-Amount of drug absorbed is inversely related to the AUC

III- It is calculated by the Trapezoidal rule

A-I only

B-III only

C-I and II only

D-II and III only

E-All of the above

22. How many meq of Mg+2 are present in50ml of 20% MgSO4 solution? (MW of MgSO4=

246gm)

A. 31.56

B. 81.30

C. 101.52

D. 41.25

E. 2.60%

23- Which one of the followings is a weakly acidic drug?

A- Erythromycin

B- Omeprazole

C- Ephedrine

D- Phenytoin

E- Ciprofloxacin

24. pH-pka = 1.5, for acidic drug what percent of drug is ionized?

A-3.06%

B-1%

C-100%

D-99%

E-97.5%

25. In insurance plan drug price is $29.00 and $6.00 prescription fee. Every time this patient

pays $10.00 for each prescription what is it called?

a. Coinsurance

b. Co-payment

c. Prescription fee

d. Gross margin

e. Donation

26. A 60 year old patient is suffering from CHF. He is taking Captopril 25mg tid and

Carvedilol 25mg bid. His LVEF= 35%, BP= 115/82, Creatinine clearance= 65ml/min,

Serum potassium=6.15mmol/L, Serum sodium= 140meq/L.

Which of the followings should Not be added to this patient?

A- Digoxin

B- Furosemide

C-Spironolactone

D-Hydrochlorothiazide

E-All of the above

27-What is Not true about distribution of a drug in the systemic circulation?

I. Drug is distributed more slowly to tissues with low blood flow

II. Extensive protein binding helps the drug molecule to cross the cell membrane easily

III. Polar drugs cross blood-brain barrier more rapidly

A.I only

B. III only

C.I and II only

D. II and III only

E. All of the above are correct

28. If the total body clearance of a drug is 200 mL/min in a normal healthy adult and the renal

clearance is 10 mL/min then one may assume that;

I. Higher percent of plasma protein bound drug.

II. Drug has tubular re-absorption

III. It is extensively metabolized in the body

A.I only

B. III only

C.I and II only

D. II and III only

E. All of the above are correct

29- A researcher develops a new drug to prevent the common cold in children over the of two. 1000 children received placebo and 1000 received the drug. During the one-year follow up the

research diagnosed colds in 2.5% of the kids on placebo and in 2% of the active treatment.

What is the absolute risk reduction?

A-0.5%

B-20%

C-10%

D-40%

E-5%

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