Review Exercise # 44

PRACTICE QUESTIONS

Exercise # 44

Q1. Which of the following are not true with regards to metabolism of amines?

     a. 1⁰ amines undergo oxidative deamination, acetylation and    N oxidation.

     b. 2⁰ amines undergo acetylation, oxidative N dealkylation     and N oxidation.

     c. 3⁰ amines undergo oxidative N dealkylation and N oxidation.

     d. Aromatic amines can be acetylated.

     e. None of the above

Ans:  E Primary amines are the only ones that undergo phase I (deamination). Tertiary amines do not undergo acetylation.N oxidation (NH à NOH) is possible in all.

Q2. Which of the following are true with regards to Ipratropium bromide?

     a. Its an basic compound

     b. It’s an acidic compound

     c. Neither acidic nor basic, but contains a permanent +ive    charge

     d. It has no difficulty crossing the Lipid membranes.

     e. all except a.

Ans: C   It is a quaternary ammonium compound, is water solube.

Q3. Which of the following are true with regards to OH groups?

I. 1⁰ alcohols are oxidized to aldehydes and later to carboxylic acids

II. 2⁰ alcohols are oxidized to ketones.

III.3⁰ alcohols are oxidized to ketones and later to aldehydes

a. I Only

b. III Only

c. I & II only

d. II & III only

e. All

Ans: C 3⁰ are not usually oxidized. Oh groups can also undergo Glucronidation and Sulfate Conjugation.

Q4. Which of the following are true with regards to metabolism?

I. Ketones are reduced to carboxylic acids.

II. Esters and lactones are hydrolyzed to alcohols and carboxylic acids

III.Amides and lactams are hydrolyzed to amines and carboxylic acids

a. I Only

b. III Only

c. I & II only

d. II & III only

e. All

Ans: D ketones are hydrolyzed to Alcohols.

Q5. Which of the following do not impart lipophilicity to a molecule?

     a. Alkyl groups (C-C-C-C)

     b. Alkenes(C=C-C=C=C)

     c. Aromatic hydrocarbons (Ring)

     d. Ether(C-O-C)

     e. Indole nitrogen (C-NH-C inside a ring ex serotonin)

Ans: E

Q6. What are the roles of halides in a chemical structure?

I. The are electron withdrawing functional groups

II. They are used to lock the configuration of a molecule

III.They are used to decrease aromatic oxidation of a drug.

a. I Only

b. III Only

c. I & II only

d. II & III only

e. All

Ans: E    Halides are F, Cl, Br, I.

Q7. With respect to halides which of the following are false?

     a. Fluorine serves as an H bond acceptor

     b. None of the other halides participate in bonding with the receptors

     c. Fluorine is the largest halide

     d. Aromatic halides are normally not metabolized

     e. Alkyl halides undergo Oxidative dehalogenation to form      aldehydes.

Ans: C

Q8. Naturally occurring Amino acids are

     a. L α amino acids

     b. L β amino acids

     c. D α amino acids

     d. D β amino acids

     e. L α and D β amino acids

Ans: A

Q9. Proteins are made up of how many different AA's?

     a. 20

     b. 15

     c. 25

     d. 22

     e. 26

Ans: A

Q10. Purines and pyrimidines can exhibit

     a. Tautomerism

     b. Bioisoteroism

     c. Enantiomerism

     d. Geometrical isomerism

Ans: Tautomerism is a type of stereoisomerism ( keto( lactam) & enol( lactim) form)

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