PRACTICE QUESTIONS
Exercise # 43
Q1. Multiple sclerosis is treated with
a.
Baclofen & Dantralene
b.
ACTH
c.
IFN β 1b & 1a
d.
Glatiramer acetate
e.
All of the above
Q2.Which of the following are not true with regards to DNA
transfer?
a. TRANSFORMATION
involves the recipient cell taking up cell
free, fragmented (naked) DNA
b.
CONJUGATION involves two mating types, and an extra chromosomal fraction (F factor)
c.
TRANSDUCTION is the transfer of genetic material by bacteriophages
d.
BACTERIOPHAGES are bacteria that infect (enter) virus
e.
None of the above
Q3. The units for measurement of AUC is
a.
μg*hr
b.
μg*hr/ml
c.
mg/ml*hr
d.
mg*hr/ml
Q4. What type of statistical test is done to
compare bioavailability (Brand Vs Generic) comparison?
a.
t test
b.
ANOVA
c.
Chi square test
d.
f test
e.
Standard deviation test
Q5.Onset time (drug action) is determined by
a.
the time from drug administration to the MEC
b.
the time from drug administration to MTC
c.
When all the receptors are fully occupied
d.
when the TI is within limit
Q6. Which of the following are correct with
respect to the intensity (Efficacy) of the pharmacological effect?
a.
It is proportional to the number of receptors occupied by the drug up to the maximum effect
b.
It depends on the half life
c.
It is indirectly proportional to the MTC
d.
It is indirectly proportional to MEC
Q7.For two drugs to be considered
bioequivalent, which of the following are true?
I. There should be no statistical difference
between the extent of bioavailability of the drug from the test product compared to the reference
II. The 90% confidence intervals about the
ratio of the means of the Cmax and AUC values for the test product/reference product must be within 80 –
125% of the reference product.
III.There should be no statistical
differences between the mean Cmax and
AUC values for the test product compared to the
reference product.
a. I
Only
b. III
Only
b. I
& II only
d. II
& III only
e.
All of the above
Q8. Acid functional groups are
I. Imide ( CO-NH-CO)
II. Tetrazole ( N=N-NH-N=C-)
III.Imine ( C=N)
a. I
Only
b. III
Only
b. I
& II only
d. II
& III only
e.
All of the above
Q9. Which of the following are not basic
drugs?
a.
Guanethidine
b.
Hydralazine
c.
Lorazepam
d.
Chlorpropamide
e.
Prazosin
Ans: D it is sulfonylurea.
Q10. Metabolism of Carboxylic acid is by
I. Glucronidation
II. Glycine conjugation
III. Glutamine conjugation
a. I
Only
b. III
Only
b. I
& II only
d. II
& III only
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