Exercise # 33

PRACTICE QUESTIONS

Exercise # 33

Q1. The peripheral conversion of levodopa to dopamine causes

a. Nausea & vomiting

b. Cardiac arrhythmias

c. Postural hypertension

d. a & b only

e. All the above

Q2.  With regards to carbidopa which of the following are correct?

a. It is a dopa decarboxylase inhibitor

b. It is necessary to give atleast 100mg per day

c. Carbidopa in high doses can control hand rolling tremor of parkinsons disease

d. All the above

e. a & b only 

Q3.  Levodopa causes which of the following side effects?

I. Bradycardia

II. Postural Hypertension

III.Hematological effects - Hemolytic anemia, leucopenia, and agranulocytosis.

a. I Only

b. III Only

c. I & II only

d. II & III only

e. All

Q4.  Which of the following amino acids increase the clinical signs of Parkinson's?

a. Methionine

b. valine

c. Phenylalanine

d. Threonoine

e. Isoleucine 

Q5.  Direct acting dopamine agonist function by

a. They mimic dopamine agonists and decrease motor fluctuations

b. They may have a direct antioxidant effect

c. Unlike L dopa, dyskinesias are less common

d. All of the above 

Q6.  Which of the direct acting dopamine agonists cause first dose phenomenon?

a. Ergotamine

b. Pergolide

c. Pramipexole

d. Ropinirole

e. a and b only. 

Q7.  Pulmonary infiltrates, erythromelalgia and retroperitoneal fibrosis are common with

a. Direct acting D agonist

b. Levodopa

c. Seligiline

d. All of the above

e. a only 

Q8.  Which Parkinson's drug decreases the serum concn of LH?

a. Bromocryptine

b. Pergolide

c. Levodopa

d. Selegiline

e. Carbidopa

Q9.  With regard to Selegiline which of the following are correct 

I. A selective inhibitor of MAO B

II. Its site of action is CNS

III.It is a non selective MAO Inhibitor

a. I Only

b. III Only

c. I & II only

d. II & III only

e. All

Q10.  Amatadine acts by

I. Influencing the synthesis and release of dopamine

II. Decreasing presynaptic reuptake of dopamine

III. Preventing the demethylaion of dopamine in the CNC

a. I Only

b. III Only

c. I & II only

d. II & III only

e. All

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